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Ise Ekiti (; Yoruba: Ìṣẹ̀-Èkìtì, also Ise) is a city in Ekiti State, Nigeria. It is the traditional home of Akinluaduse, also known as Akinluse by the inhabitants of the city. Akinluse was a great warrior in the ancient ife Empire. Ise-Ekiti is the headquarters of the Ise/Orun Local Government Area, along with Orun.

Its geographic coordinates are 7°27′36″N 5°25′12″E. Ise ekiti is divided into three quarters namely; Oraye, Odo Ise and Erinwa. The Arinjale of Ise-Ekiti is Oba Ayodele Ajayi Aweloye II. .

As of 2007 Ise local government had an estimated population of 204,022.